GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6715284 | 1 | rs6715380 | chr2:202214505 | PPIL3 | chr2:201735680-201753999:- | -0.71 | -8.03 | 7.52E-15 | Rheumatoid arthritis |
| THCA | cis | rs9309473 | 1 | rs6715819 | chr2:73772309 | ALMS1P | chr2:73872046-73912692:+ | 0.72 | 11.1 | 1.28E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6715819 | chr2:73772309 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.74 | 1.71E-8 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6715819 | chr2:73772309 | TPRKB | chr2:73956957-73964517:- | -0.15 | -3.66 | 0.000283 | Metabolite levels |
| THCA | cis | rs7116495 | 1 | rs671681 | chr11:71782812 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.81 | 0.000158 | Severe influenza A (H1N1) infection |
| THCA | cis | rs1395 | 1 | rs6717980 | chr2:27452784 | C2orf28 | chr2:27434899-27440044:+ | 0.16 | 4.83 | 1.84E-6 | Blood metabolite levels |
| THCA | cis | rs1395 | 1 | rs6717980 | chr2:27452784 | SLC5A6 | chr2:27422459-27435071:- | -0.32 | -6.9 | 1.64E-11 | Blood metabolite levels |
| THCA | cis | rs4853036 | 1 | rs6718012 | chr2:70078258 | SNRNP27 | chr2:70121090-70132348:+ | 0.17 | 3.94 | 9.34E-5 | Colorectal or endometrial cancer |
| THCA | cis | rs1561288 | 1 | rs6718083 | chr2:25362194 | POMC | chr2:25383722-25391559:- | 0.24 | 3.95 | 9.06E-5 | Body mass index |
| THCA | cis | rs67180937 | 1 | rs67180937 | chr1:222823743 | AIDA | chr1:222841357-222886526:- | 0.18 | 4.7 | 3.4E-6 | Coronary artery disease |
| THCA | cis | rs67180937 | 1 | rs67180937 | chr1:222823743 | TAF1A | chr1:222731244-222763255:- | 0.15 | 3.61 | 0.000339 | Coronary artery disease |
| THCA | cis | rs6547741 | 1 | rs6718128 | chr2:27833752 | FNDC4 | chr2:27714751-27718126:- | 0.15 | 3.46 | 0.000598 | Oral cavity cancer |
| THCA | cis | rs8020441 | 1 | rs67186984 | chr14:51169287 | SAV1 | chr14:51100360-51135023:- | 0.31 | 6.5 | 2.01E-10 | Cognitive performance |
| THCA | cis | rs4664308 | 1 | rs6719686 | chr2:160908292 | LY75 | chr2:160625141-160761262:- | 0.21 | 4.95 | 1.02E-6 | Idiopathic membranous nephropathy |
| THCA | cis | rs4665809 | 1 | rs6720314 | chr2:26334852 | GPR113 | chr2:26531041-26569685:- | -0.47 | -7.22 | 2.05E-12 | Gut microbiome composition (summer) |